<i>CCT4</i> as a prognostic biomarker correlated with immune infiltration and hepatocyte dedifferentiation in hepatocellular carcinoma.

ABSTRACT:

Background

CCT4 is a key molecular chaperone and its dysfunction may impair actin or microtubule assembly, potentially driving hepatocellular carcinoma (HCC) progression. However, its roles in multiple cell types and tumor microenvironment infiltration in HCC remain unclear. This study aimed to investigate the biological functions of CCT4 in HCC by integrating single-cell and bulk transcriptomic data.

Methods

CCT4 expression in HCC was analyzed using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Functional analyses were conducted via Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA). Furthermore, Cox regression analysis and nomogram construction were employed to assess patie

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12605557 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature