Epidemiological characteristics and prognostic factors of high-grade brainstem glioma for all ages and the establishment of a nomogram.

ABSTRACT:

Background

High-grade brainstem gliomas (HGBSGs) are aggressive tumors with dismal prognoses. Large-scale studies across all ages are needed to clarify their characteristics and identify predictors of cancer-specific mortality. This study sought to use data from the Surveillance Epidemiology and End Results (SEER) database to conduct a population-based analysis of HGBSG patients of all ages, identify factors influencing cancer-specific survival (CSS), and develop nomograms for prognostic prediction.

Methods

We retrospectively analyzed patients with pathologically confirmed brainstem high-grade gliomas using the SEER database from 2000 to 2018. Univariate and multivariate Cox regression, which included patient demographics, tumor characteristics, and treatments were used to i

SUBMITTER: Huang B 

PROVIDER: S-EPMC12605596 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature