TIPE3 promotes breast cancer progression and metastasis via the AKT-GSK3β-β-catenin/Snail pathway.

ABSTRACT:

Background

The tumor necrosis factor-α-induced protein 8-like 3 (TNFAIP8L3, TIPE3) plays a critical role in phosphoinositide transport and metabolism to facilitate PI3K-AKT signaling activation. Elevated TIPE3 expression has been observed in multiple malignancies, including esophageal, cervical, colon, and lung cancers, suggesting its potential oncogenic role in tumor progression. However, the precise molecular mechanisms by which TIPE3 regulates breast cancer progression remain largely unclear. This study aims to investigate the role of TIPE3 in breast cancer cell growth and metastasis.

Methods

TIPE3 expression in 100 paired breast cancer and adjacent tissues was analyzed via immunohistochemistry. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot a

SUBMITTER: Bai Y 

PROVIDER: S-EPMC12605601 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature