Cetylpyridinium chloride and platinum nanoparticles effects in dogs with Porphyromonas gulae-infected periodontal disease.

ABSTRACT: Periodontal disease (PD) is a prevalent infectious condition in companion animals and represents an irreversible oral disorder; therefore, preventive dentistry is strongly recommended to inhibit and delay symptom progression. In this study, we investigated the synergistic effects of cetylpyridinium chloride (CPC) and platinum nanoparticles (PT) on the growth, halitosis, and inflammatory responses of the major canine PD pathogen Porphyromonas gulae (P. gulae) both in vitro and in a clinical study involving PD-affected dogs following dental scaling. The growth of P. gulae was significantly inhibited by CPC + PT treatment. Hydrogen sulfide and methyl mercaptan-key components of halitosis-produced by P. gulae were also significantly suppressed by the CPC and PT mixture, even after short-term t

SUBMITTER: Fukuyama T 

PROVIDER: S-EPMC12605614 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature