Chest CT imaging for differentiating normal, PRISm, and COPD in comparison with pulmonary function tests.

ABSTRACT:

Background

Preserved ratio impaired spirometry (PRISm) and chronic obstructive pulmonary disease (COPD) are progressive respiratory disorders associated with accelerated pulmonary function decline and systemic comorbidities. This multicenter study aimed to develop a three-category classification model that integrates clinical variables with thoracic computed tomography (CT) radiomics to distinguish normal pulmonary function, PRISm, and COPD.

Methods

A total of 1018 participants from three centers (A, B, C) who underwent chest CT and pulmonary function tests (PFTs) within a 2-week interval were retrospectively analyzed. After applying inclusion and exclusion criteria, 797 individuals were included for analysis (Center A: 667 [training/internal test = 534:133]; Centers B, C: 1

SUBMITTER: Ma Z 

PROVIDER: S-EPMC12605617 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature