A novel approach to establish orthotopic right lung transplantation in rats.

ABSTRACT:

Background

Although the left lung transplantation model in rats is widely adopted, the right lung transplantation remains less common due to anatomical complexity and technical challenges. As the right lung contributes approximately 70% of total lung function, the orthotopic right lung transplantation model provides a more physiological and clinically relevant platform for evaluating graft function, particularly during the survival period, compared to the commonly used left lung model. In this study, we developed a novel orthotopic right lung transplantation technique based on our previous "pendulum model" in rats, incorporating several innovations to enhance accessibility for beginners and provide a more feasible and reliable platform for basic research.

Methods

Twenty cons

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12605638 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature