Deciphering the potential pathogeny of rare tracheal adenoid cystic carcinoma by single-cell RNA-sequencing.

ABSTRACT:

Background

Tracheal adenoid cystic carcinoma (TACC) is an extremely rare type of cancer, characterized by slow growth, but high rates of recurrence and metastasis. The treatment of TACC is greatly hampered by the limited understanding of its molecular characteristics. We sought to conduct an in-depth analysis of this type of cancer through single-cell RNA-sequencing (RNA-seq) to provide important evidence for the formulation of treatment strategies for TACC.

Methods

The peripheral blood, tumor tissue, and adjacent tissue of the same TACC patient was obtained and tested by single-cell RNA-seq. A bioinformatics analysis was conducted to identify the cell clones with key biological functions and determine their molecular characteristics. Fluorescent multiplex immunohistochemist

SUBMITTER: Li J 

PROVIDER: S-EPMC12605701 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature