LINC01314 suppresses proliferation and invasion via epithelial-to-mesenchymal transition regulation in lung adenocarcinoma.

ABSTRACT:

Background

Long intergenic non-protein coding RNA 1314 (LINC01314) is significantly downregulated in lung adenocarcinoma; however, its functional role in tumor progression remains unclear. We investigated the impact of LINC01314 on lung adenocarcinoma aggressiveness and explored the underlying mechanisms.

Methods

Expression levels of LINC01314 and its association with clinicopathological features and patient survival were evaluated using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. In vitro, lung adenocarcinoma cell lines A549 and H1299 were used to assess the effects of LINC01314 knockdown and overexpression on cell proliferation, migration, and invasion by Cell Counting Kit-8 (CCK-8), wound healing, and transwell assays, respectively.

SUBMITTER: Zhu W 

PROVIDER: S-EPMC12605721 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature