Mortality in patients with secondary peritonitis treated by primary closure or vacuum-assisted closure: nationwide register-based cohort study.

ABSTRACT:

Background

Secondary peritonitis caused by gastrointestinal perforation is associated with significant morbidity and mortality. Effective management includes surgical source control, antibiotic therapy, and intensive resuscitation. The choice between primary abdominal closure (PAC) and vacuum-assisted closure (VAC) in the management of secondary peritonitis remains a subject of debate.

Methods

This Danish nationwide register-based cohort study included patients undergoing emergency surgery for secondary peritonitis from perforation of the small intestine, colon, or rectum between 2007 and 2021 who were treated with either PAC or VAC. Data were extracted from national registries, including the Danish Register of Cause of Death and the Danish National Patient Registry. The pri

SUBMITTER: Rajabaleyan P 

PROVIDER: S-EPMC12605727 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature