Omitting radiotherapy in LUMINA-like breast cancer after breast conserving surgery: 10-year results of a population-based cohort study.

ABSTRACT:

Background

Recently, the LUMINA trial reported 5-year results of omitting radiotherapy in a low-risk cohort after breast-conserving surgery (BCS). This study aimed to validate their 5-year results and investigate 10-year outcomes of patients satisfying their criteria in a population-based cohort.

Materials and methods

A total of 28 185 eligible patients were identified from the Surveillance, Epidemiology and End Results (SEER) database to establish SEER-LUMINA cohort. The Kaplan-Meier method was employed to estimate recurrence incidence and survival outcomes. Matched cohorts were generated using propensity score matching (PSM). The Cox proportional hazards model was used to generate hazard ratios.

Results

A total of 6808 patients of the 28 185 did not receive radiothe

SUBMITTER: Wang S 

PROVIDER: S-EPMC12605746 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature