Integration of single-cell and bulk transcriptomics to explore prognostic and immunotherapeutic characteristics of sodium overload-induced cell death in lung adenocarcinoma.

ABSTRACT:

Background

Recent studies have identified a novel cell death mechanism, termed sodium death, triggered by sustained activation of TRPM4 ion channels. Prolonged TRPM4 channel activity results in excessive sodium ion influx and membrane depolarization, ultimately inducing necrotic cell death. However, the role of sodium death-associated genes (NECSOs) in lung adenocarcinoma (LUAD) remains poorly understood. We used NECSOs to construct a prognostic model of LUAD for prognostic prediction and to explore the features of sodium overload-induced cell death in single cells.

Methods

This study conducted a comprehensive analysis of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases to investigate TRPM4, a NECSO identified in the literature.

SUBMITTER: Shi Y 

PROVIDER: S-EPMC12605749 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature