Outcome prediction of oestrogen receptor-positive breast cancer based on a panel of oestrogen receptor-regulated genes.

ABSTRACT:

Background

The response of oestrogen receptor-positive (ER+) breast cancers (BC) to endocrine therapy (ET) is variable. ER pathway-regulated genes have been proposed to play a role in response to ET. In this study, we investigated the prognostic and predictive impacts of the expression of key ER-regulated genes in BC.

Methods

The Cancer Genome Atlas data was used to identify differentially expressed genes (DEG) associated with ER-positivity. Of the DEGs (1329 upregulated and 1188 downregulated genes), 21 top genes showed biological and clinical relevance to ER functions and were further investigated. Publicly available transcriptomic datasets were utilised to evaluate the clinical significance of the expression of these 21 genes. The well-characterised Nottingham operable BC

SUBMITTER: Makhlouf S 

PROVIDER: S-EPMC12605772 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature