Unveiling <i>PIK3CA</i> mutation: a prognostic beacon in endometrial carcinoma and its immune implications.

ABSTRACT:

Background

Endometrial carcinoma (EC) is a prevalent gynecological malignancy with diverse genetic underpinnings. This study aimed to elucidate the prognostic significance of genetic mutations, particularly PIK3CA, and their impact on immune landscape and therapeutic outcomes in EC.

Methods

Clinical and RNAseq data were acquired from cBioPortal and The Cancer Genome Atlas (TCGA). These data were utilized for prognostic analysis. Immune landscape analysis using single sample Gene Set Enrichment Analysis (ssGSEA) revealed enhanced infiltration of immune cells in PIK3CA-mutated samples. A PIK3CA-related risk model was constructed using least absolute shrinkage and selection operator (LASSO) regression. A nomogram was used the results derived from Cox univar

SUBMITTER: Cao S 

PROVIDER: S-EPMC12605787 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature