Impaired Treg-Mediated Immune Regulation in Peri-Implantitis Lesions and Implant Loss: Insights From Histological and Molecular Analyses.

ABSTRACT:

Aim

To evaluate the T regulatory lymphocyte (Treg) profile and its potential contribution to peri-implant tissue destruction during peri-implantitis (PI).

Methods

PI granulation tissue and crevicular fluid collected during PI surgical (PI group, n = 23) and explantation (PI-X group, n = 23) therapy, with peri-implant healthy tissue from second-stage surgery (H group, n = 20) as controls, were analysed. The inflammatory infiltrate was characterised by H&E staining. The relative expression of Treg-associated transcription factors and cytokines was assessed by RT-qPCR. Forkhead box P3 (FOXP3) and neuropilin (NPR)-1 were detected by immunohistochemistry, and interleukin (IL)-10, TGF-β1 and IL-35 by ELISA. The clinical parameters, namely probing depth (PD), bleeding on probing (B

SUBMITTER: Cafferata EA 

PROVIDER: S-EPMC12605793 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature