Clinical Implications of Time to Culture Conversion in <i>Mycobacterium Avium</i> Complex Pulmonary Disease.

ABSTRACT:

Background

The optimal timing for assessing treatment response in Mycobacterium avium complex pulmonary disease (MAC-PD) remains unclear. This study evaluated the association between time to culture conversion and microbiological cure.

Methods

We retrospectively included MAC-PD patients treated at Seoul National University Hospital between January 2011 and April 2024 who achieved culture conversion within 12 months of treatment initiation. Patients were categorized by time to culture conversion: 0-30, 31-60, 61-90, 91-180, and 181-360 days. Multivariable logistic regression was used to assess the impact of conversion timing on microbiological cure.

Results

Among 440 patients, 294 (66.8%) achieved microbiological cure. Compared with those who converted within 30

SUBMITTER: Kwak N 

PROVIDER: S-EPMC12605800 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature