Healthy lifestyles, screening, and breast cancer mortality in women with different risk of disease.

ABSTRACT:

Background

Healthy lifestyles and screening are the two major interventions to prevent breast cancer mortality. However, their effects have not been compared simultaneously, and it remains unclear whether their benefits differ by women' baseline breast cancer risk.

Methods

A prospective cohort study was conducted using the UK biobank linked to national cancer registries, including 261 398 women aged 40-70. Hazard ratios (HRs) and population attributable fractions (PAF) for breast cancer mortality were estimated in relation to healthy lifestyle index (HLI) and screening status, using a Cox regression model. We further examined the interaction between HLI, screening and breast cancer risk predictors (Tyrer-Cuzick score and polygenic risk score [PRS], using highest and lowest 2

SUBMITTER: Yang H 

PROVIDER: S-EPMC12605817 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature