Diagnostic utility of contrast-enhanced ultrasound parameters in classifying lupus nephritis.

ABSTRACT:

Background

Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE), with renal biopsy as the diagnostic gold standard. However, biopsy is invasive. This study aims to evaluate the potential of contrast-enhanced ultrasound (CEUS) quantitative parameters as non-invasive predictors in differentiation proliferative LN from non-proliferative LN.

Methods

Fifty-eight biopsy-confirmed LN patients who underwent CEUS within 3 days before biopsy were included retrospectively. Patients were categorized into 38 cases of proliferative LN (Class III, IV, and III/IV + V) and 20 cases of non-proliferative LN (Class II and purely Class V). The clinical and laboratory data, conventional US parameters, and CEUS quantitative parameters derived from time-intensity curv

SUBMITTER: Wei S 

PROVIDER: S-EPMC12605818 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature