Combined impact of gray and superficial white matter abnormalities: Implications for epilepsy surgery.

ABSTRACT:

Objective

Drug-resistant focal epilepsy is associated with abnormalities in the brain in both gray matter (GM) and superficial white matter (SWM). However, it is unknown if both types of abnormalities are important in supporting seizures. Here, we test if surgical removal of GM and/or SWM abnormalities relates to post-surgical seizure outcome in people with temporal lobe epilepsy (TLE).

Methods

We analyzed structural imaging data from 143 patients with TLE (pre-op diffusion magnetic resonance imaging and pre-op T1-weighted MRI) and 97 healthy controls. We calculated GM volume abnormalities and SWM mean diffusivity abnormalities and evaluated if their surgical removal distinguished seizure outcome groups post-surgically.

Results

At a group level, GM and SWM abnormaliti

SUBMITTER: Kozma C 

PROVIDER: S-EPMC12605822 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature