Salvianolic Acid A Mitigates Osteoporotic Bone Loss by Repressing Reactive Oxygen Species via the Nrf2-HO-1 Pathway.

ABSTRACT: Osteoporosis, characterized by osteoclastic bone resorption, has been the focus of research. Studies implicate that reactive oxygen species (ROS) accumulate intracellularly during osteoclastogenesis. Salvianolic acid A (SAA), a compound derived from Salvia miltiorrhiza, has been widely used to treat cardiovascular and cerebrovascular disorders, owing to its antioxidant and anti-inflammatory properties. In this study, we investigated the therapeutic effects of SAA on osteoporotic bone loss in vitro and in osteoporotic mice induced by ovariectomy (OVX) and explored the underpinning mechanisms. In vitro, SAA significantly restrained osteoclastogenesis and osteoclastic resorption in a dose- and time-dependent manner. SAA markedly blocked the expression of osteoclast-specific genes and proteins

SUBMITTER: Qiu H 

PROVIDER: S-EPMC12605832 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature