Characteristics of kidney stone-modulatory proteins decoded from proteins identified in stone matrix and urine of stone formers and non-stone subjects.

ABSTRACT: Kidney stone formation is a sophisticated pathogenic process regulated by several stone-modulatory proteins, namely inhibitors and promoters. However, the characteristics of these proteins that determine their modulatory activities have remained largely unknown. Herein, we investigated potential characteristics of inhibitors and promoters involved in the stone-forming process by comparing amino acid contents, various physico-chemical properties, and calcium- and oxalate-binding properties of all proteins identified from normal urine (NU), stone former urine (SFU), and stone matrix (SM). Simple comparisons among the three groups showed that SM proteins apparently differed from NU and SFU proteins for almost all parameters, whereas no significant differences were detected between NU and SFU

SUBMITTER: Koeipudsa N 

PROVIDER: S-EPMC12605856 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature