Characterization of the intraspecies chimeric mouse brain at embryonic day 12.5.

ABSTRACT: Incidence of neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis have increased dramatically as life expectancy has risen year-over-year, and can lead to neurologic changes. Neurological changes within the central nervous system, specifically the brain, include cell loss and deterioration that impact motor function, memory, executive function, and mood. Available treatments are limited and often only address symptomatic manifestations of the disease rather than disease progression. Cell transplantation therapy has shown promise for treating neurodegenerative diseases, but a source of autologous cells is required. Blastocyst complementation provides an innovative method for generating autologous neural cells. By injecting mouse induce

SUBMITTER: Strell P 

PROVIDER: S-EPMC12605873 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature