Door-to-needle performance in African ST-elevation myocardial infarction management: A systematic review and meta-analysis.

ABSTRACT:

Background

Timely fibrinolysis remains the cornerstone of reperfusion for ST-elevation myocardial infarction (STEMI) in settings without reliable access to primary percutaneous coronary intervention (PCI). International guidelines recommend a door-to-needle time (DTNT) of 30 min or less.

Aim

We conducted the first continent-wide meta-analysis to quantify real-world DTNTs and adherence to guideline benchmarks in African hospitals.

Methods

We systematically searched PubMed/MEDLINE, Scopus, and Web of Science through July 2, 2025, for studies reporting DTNT for adult STEMI patients treated with thrombolysis in Africa. Pooled mean DTNT was estimated via random-effects meta-analysis with restricted maximum likelihood and Knapp-Hartung adjustment. Heterogeneity was assessed

SUBMITTER: Sama C 

PROVIDER: S-EPMC12605892 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature