Alteration of gut microbial ecology by the direct activation of the brain: Inverse gut-microbiome-brain dynamics.

ABSTRACT: The gut-microbiome-brain axis is a bidirectional communication system influencing host physiology and overall fitness. While "bottom-up" effects-where gut microbes influence brain function and behavior-are well established, direct evidence for "top-down" modulation-where the brain shapes the gut microbial ecology-remains elusive. Here, we show that the selective expression of the bacterial ion channel mNaChBac in glutamatergic lateral habenula (LHb) neurons increases their bursting activity and leads to endophentypes associated with depression. Importantly, this chronic activation leads to changes in the gut microbiome composition over time, as reflected by shifts in alpha-diversity and alterations in specific microbial taxa. These findings provide direct evidence that the persistent activ

SUBMITTER: Wang IC 

PROVIDER: S-EPMC12605924 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature