CPZ promotes the proliferation of gastric cancer by activating the Wnt pathway through binding with DVL2.

ABSTRACT:

Background

Gastric cancer (GC) is one of the most prevalent and heterogeneous malignancies worldwide, with treatment outcomes often hindered by delayed diagnosis and limited therapeutic options. Consequently, identifying novel targets for GC diagnosis and treatment is of significant clinical relevance. This study investigated the role of CPZ in GC progression and explored its molecular mechanisms and potential as a prognostic marker and therapeutic target.

Methods

Bioinformatics analysis and clinical pathological evaluations were conducted to assess CPZ expression in GC and its correlation with clinical parameters. In vivo and in vitro experiments, including CCK8 proliferation assays, flow cytometry, and xenograft mouse models, were employed to confirm the impact of CPZ on G

SUBMITTER: Luo R 

PROVIDER: S-EPMC12605940 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature