Incidence and Long-Term Outcomes of Pouchitis in Ulcerative Colitis Patients.

ABSTRACT:

Background

Ileal pouch-anal anastomosis (IPAA) is the preferred intervention for ulcerative colitis (UC) patients whose medical treatment fails. Acute severe ulcerative colitis (ASUC) can precipitate the need for urgent surgery, potentially influencing post-IPAA outcomes.

Objective

This study details the incidence, disease course, and treatment of pouchitis and pouch failure in a population-based cohort of UC patients following IPAA construction.

Methods

We included all UC patients who underwent IPAA construction within two administrative regions in Denmark between November 1993 and April 2021 in a population-based cohort. Data spanning from diagnosis to January 2023 were manually extracted from electronic patient records and analyzed.

Results

Among 233 patient

SUBMITTER: Bergstrom R 

PROVIDER: S-EPMC12605964 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature