Groundbreaking Insights Into SIRT1/NRF2-Mediated Ferroptosis Inhibition by Resveratrol in Parkinson's Disease Models.

ABSTRACT:

Background

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, characterized by the degeneration of dopamine (DA) neurons in the substantia nigra (SN) of the midbrain. Recent studies have highlighted the role of ferroptosis in neuronal death, with elevated peroxide levels being a hallmark of this process. Resveratrol (RSV), a natural compound, has shown promise as a neuroprotective agent. This study explores the potential of RSV in mitigating ferroptosis in PD and elucidates its mechanisms.

Methods

Network pharmacology was employed to predict the interactions between RSV, ferroptosis, and PD-related targets. Cytoscape protein-protein interaction (PPI) analysis identified key potential targets, while Gene Ontology (GO) and Kyoto Encyclopedia of G

SUBMITTER: Zheng Q 

PROVIDER: S-EPMC12605972 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature