Mapping the stage-specific plasma p53 interactome reveals colorectal cancer progression signatures and therapeutic vulnerabilities.

ABSTRACT: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide, yet the molecular changes that occur in the bloodstream as the disease advances remain poorly understood. In particular, how p53-a key tumor suppressor-interacts with circulating proteins at different stages of CRC has not been well characterized. In this discovery-phase study, we analyzed plasma samples from patients with CRC stages I-IV using high-resolution LC-MS/MS. Stage-specific proteins were identified and cross-validated with transcriptomic data, revealing TP53 as a central hub in multiple functional networks. Enrichment analyses highlighted progressive changes in pathways linked to immune surveillance, complement activation, and cellular stress responses. Early-stage disease showed signals consi

SUBMITTER: Natarajan RA 

PROVIDER: S-EPMC12606009 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature