Delphi Consensus on Attenuated Androgen Use for Long-Term Prophylaxis in Hereditary Angioedema: AURA Project.

ABSTRACT:

Background

Danazol and other attenuated androgens (AAs) have been a cornerstone of Hereditary Angioedema (HAE) long-term prophylaxis (LTP) for decades, alongside intravenous plasma-derived C1INH (pdC1INH). Danazol's potential androgenic effects, however, present several limitations to its prescription and use. With the emergence of safer and more effective LTP drugs, guidelines are now shifting danazol to a second-line option. These changes in HAE therapy require a new framework to guide physicians in the appropriate use of danazol in HAE LTP.

Methods

This study aimed to develop a consensus on key aspects of danazol management, including discontinuation strategies, through a 2-round Delphi methodology. Statements were defined by a steering committee of both Endocrinology and

SUBMITTER: Dias de Castro E 

PROVIDER: S-EPMC12606019 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature