A Causal Association Between Drug Use and Cognitive Impairment: A Two-Sample Mendelian Randomization Study.

ABSTRACT:

Introduction

Observational studies have suggested a link between certain drugs and cognitive impairment. In this study, a two-sample Mendelian randomization (MR) approach was used to investigate the causal relationship between drug use and different types of dementia.

Methods

We utilized summary data from genome-wide association studies (GWAS) with populations of European ancestry. The primary analysis was conducted using inverse-variance weighted (IVW) methods; MR Egger, weighted median, and weighted model methods were used to validate the results. Horizontal pleiotropy and outlier detection were assessed via MR Egger and MR-PRESSO, respectively; Cochran's Q test evaluated heterogeneity, whereas leave-one-out analyses were used to evaluate the presence of predominant instru

SUBMITTER: Yan B 

PROVIDER: S-EPMC12606049 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature