Regioselective C(sp³)-H borylation <i>via</i> a diarylboryl anion surrogate in sp²-sp³ diboranes(5).

ABSTRACT: Transition-metal-free C-H functionalization is a long-standing goal in synthetic chemistry. While a few main-group species have shown promise in C(sp²)-H activation through insertion or nucleophilic aromatic substitution (S_NAr) pathways, C(sp³)-H functionalization remains underdeveloped due to the intrinsic inertness of saturated carbon centers and the insufficient reactivity of reported main-group species. Herein, we report regioselective C(sp³)-H borylation in sp²-sp³ diboranes(5), mediated by a highly reactive B(o-tolyl)₂ ^- surrogate. It selectively inserts into α-C(sp³)-H bonds of alkyl groups to generate a family of anionic 1,1-diborylalkyl species. The resulting anions are readil

SUBMITTER: Mao X 

PROVIDER: S-EPMC12606078 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature