Inhibition of NLRP3 inflammasome activation alleviated liver injury and wasting effect in tumor-bearing mice.

ABSTRACT: This study is designed to evaluate the changes in tumor-bearing mice, as well as to assess the role of NLRP3 in muscle atrophy and its function in the liver of tumor-bearing mice. In this study, RNA-seq data from the liver of Colon26 (C26) tumor-bearing mice were used to perform pathway enrichment analysis. We established a cancer cachexia model by subcutaneous injection of C26 cells, MCC950 was injected intraperitoneally at a concentration of 30 mg/kg on day 12. On day 21, the mice were dissected, the tissues were weighed, and the specimens were fixed for subsequent staining. In our study, by analyzing RNA-seq data, we found that the inflammatory response was significantly activated in the liver of Colon26 (C26) tumor-bearing mice with up-regulation of several inflammatory cytokines, incl

SUBMITTER: Wu S 

PROVIDER: S-EPMC12606107 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature