In-silico discovery of druggable molecular signatures that drive dengue fever to severe dengue fever highlighting common pathogenesis through single-cell RNA-Seq analysis.

ABSTRACT: Dengue, also known as dengue fever (DF), is an infection spread by mosquitoes. It infects over 400 million people globally each year. Sometimes DF progresses to severe DF (sDF) for which patients suffer from life-threatening complications including internal bleeding, failure of cardiovascular systems and death. Although DF is a severe threat to human life, its diagnosis and therapeutic strategies have not yet reached a satisfactory level. In order to address these issues, at first, this study identified six key cell-types (myeloid dendritic cells (DCs), memory B cells, naive B cells, memory CD4 T cells, plasmacytoid DCs, and plasmablasts) associated with both DF and sDF by integrating two single-cell RNA-Seq (scRNA-seq) profile datasets (GSE220969 and GSE154386) and cell-cell communication

SUBMITTER: Al Noman M 

PROVIDER: S-EPMC12606108 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature