Estimated glucose disposal rate and risk of incident hyperuricemia: insights from CHARLS.

ABSTRACT: Hyperuricemia (HUA) is a widespread public health problem worldwide, the etiology of HUA is complex, and there is still a lack of accurate indicators to assess HUA when conducting mass epidemiologic screening. Recent studies have shown that insulin resistance (IR) contributes to the development of HUA, and the estimated glucose disposal rate (eGDR) has been recognized as a reliable surrogate for IR. The aim of this study was to investigate the association between eGDR and incident HUA. A total of 9091 participants without HUA at baseline were enrolled in the China Health and Retirement Longitudinal Study. Multivariate logistic regression models were used to analyze the association between eGDR and incident HUA. Restricted cubic spline (RCS) regression modeling was used to examine the dose-

SUBMITTER: Liao Y 

PROVIDER: S-EPMC12606124 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature