Unraveling porcine dendritic-cell diversity: welcome tDC and DC3.

ABSTRACT: Dendritic cells (DC) are professional antigen presenting cells playing a major role in orchestrating adaptative immune responses. To adapt to various immune challenges, such as different classes of pathogens, specialized subsets of DC have evolved across species. To date, DC are classified as conventional DC (cDC1, cDC2) and plasmacytoid DC (pDC), with the more recent addition of DC3 and transitional DC (tDC) that were discovered in human and mouse thanks to high-dimensional phenotyping and single-cell sequencing technologies. Here, by combining flow cytometry and RNA-seq on the bulk- and single-cell level, we identified the porcine equivalent of tDC in blood as CD14^-CADM1^-CD172a⁺CD4^- cells expressing both Flt3 and CD123 (IL-3RA). This new subset

SUBMITTER: Baillou A 

PROVIDER: S-EPMC12606228 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature