Integrated individually addressable microneedle arrays for robust glucose monitoring and on-demand insulin releasing.

ABSTRACT: Real-time glucose monitoring and adaptive insulin administration are critical for effective diabetes management. Minimally invasive microneedle-based glucose monitoring sensors offer a promising approach but suffer from signal drift due to tissue reactions, inconsistent implantation, or mechanical damage to their sensitive layers during insertion. Moreover, microneedle-based insulin delivery faces limitations in achieving accurate and quantitatively controlled release due to its passive response mechanism. Here, we report a minimally invasive platform integrating a multiplexed glucose biosensor array with on-demand insulin delivery for precise glycemic control. To prevent the impact of potential individual microneedle failure post-insertion, the system incorporates a redundant sensing arra

SUBMITTER: Wei Y 

PROVIDER: S-EPMC12606245 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature