Optimization strategies for reversible myocardial injury caused by ultrasonic cavitation effects using an orthogonal experimental design.

ABSTRACT: The aim of this study is to investigate the effect of the optimal parameter combination of ultrasonic cavitation on reversible myocardial injury in rat heart using an orthogonal experimental design. An orthogonal experimental design was used to inject microbubbles via the tail vein at a certain microbubble concentration and input speed, and to irradiate the long-axis section of the rat left ventricle according to different levels of mechanical index (MI), duty cycle (DU), and irradiation time (IT), respectively. Myocardial injury was assessed by serum levels of lactate dehydrogenase (LDH). Cardiac function was measured by echocardiography and two-dimensional spot tracking. Myocardial blood perfusion was evaluated using peak signal intensity (PI). The expression levels of apoptosis related

SUBMITTER: Zhao L 

PROVIDER: S-EPMC12606301 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature