Design, synthesis, characterization, biological investigation and docking studies of newly synthesized sulphonyl hydrazide and their derivatives.

ABSTRACT: Numerous medications, including non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids, are available to treat inflammation. However, due to their side effects, the search for new anti-inflammatory drugs remains a major research focus. The current study addresses the synthesis, characterization of sulphonyl hydrazide, followed by in vitro and in silico analyses. Sulphonyl hydrazide compounds (R1-R5) were synthesized and characterized using physicochemical and spectroscopic methods, followed by anti-inflammatory evaluation and in silico approaches. The COX-2 and 5-LOX pathways were used for anti-inflammatory potential of compounds. The test compounds (R1-R5) showed significant activity (P < 0.05) against various in vitro enzymes. The compound R3 exhibited remarkable potency in i

SUBMITTER: Rahman M 

PROVIDER: S-EPMC12606314 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature