Levodopa exposure and nigral neuroinflammation in parkinsonian disorders: A postmortem study of 63 cases.

ABSTRACT: Levodopa remains the cornerstone of treatment in Parkinson's disease (PD), but its long-term impact on neuroinflammation remains unclear, particularly in multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), where levodopa efficacy is limited. This study examined whether chronic levodopa exposure is associated with neuroinflammation or dopaminergic neuronal loss in end-stage PD, MSA, and PSP. Postmortem midbrain tissue from 63 neuropathologically confirmed cases (PD: n = 38; PSP: n = 13; MSA: n = 12) was analyzed. Immunohistochemistry was used to quantify tyrosine hydroxylase positive (TH+) neurons in the substantia nigra pars compacta (SNc), along with T lymphocyte (CD3+, CD4+, CD8+) infiltration and microglial density (Iba1 expression). Levodopa exposure was estimated u

SUBMITTER: Backman EA 

PROVIDER: S-EPMC12606330 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature