The associations between diet-induced inflammation and health outcomes: a population-based phenome-wide association study.

ABSTRACT: Evidence linking the dietary inflammatory index (DII) to health outcomes remains inconsistent and limited. This study assessed the associations between DII and 845 health outcomes (N = 78,390 to 207,832), identifying 133 outcomes significantly associated with DII after multiple comparison correction (P_FDR < 0.05). Most of these health outcomes pertained to the digestive, circulatory, and endocrine/metabolic systems. Using the genetic instrument rs7910002, significantly associated with DII at the genome-wide level (P < 5 × 10^-8), Mendelian randomization (MR) phenome-wide association analysis (N = 121,978 to 315,586) revealed significant associations between DII and 25 health outcomes (P_FDR < 0.05). Consistent effects of DII on seven health outcomes were obse

SUBMITTER: Chen W 

PROVIDER: S-EPMC12606353 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature