Distinct routes to thermotolerance in the fungal pathogen Cryptococcus neoformans.

ABSTRACT: Increasing temperatures associated with climate change have the potential for far-reaching impacts on human health and disease vectors, including fungal pathogens. Pathogenic fungi inhabit a wide range of environments across the world, and their ranges have been slowly expanding in recent decades due, in part, to climate change. Despite these links between increasing temperature and higher prevalence of fungal disease, the direct effects of rising environmental temperatures on the evolution of pathogenic fungi remain unclear. In this study, we investigated how increasing temperatures drive adaptive evolution in the human fungal pathogen Cryptococcus neoformans. First, we performed serial passages of a C. neoformans environmental isolate with gradual changes in temperature over the course o

SUBMITTER: Schwiesow MJW 

PROVIDER: S-EPMC12606428 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature