Genotype-by-environment interactions shape ubiquitin-proteasome system activity.

ABSTRACT: In genotype-by-environment interactions (GxE), the effect of a genetic variant on a trait depends on the environment. GxE influences numerous organismal traits. However, we have limited understanding of how GxE shapes molecular processes. Here, we characterized how GxE shapes protein degradation, an essential molecular process that affects cellular and organismal physiology. Using 2 isolates of the yeast Saccharomyces cerevisiae, we profiled GxE in the ubiquitin-proteasome system (UPS), the primary protein degradation system in eukaryotes. By measuring UPS degradation activity toward 6 substrates that engage multiple distinct UPS pathways across 8 diverse environments, we discovered extensive GxE in the genetics of the UPS. The effects of all environments, including environments previously

SUBMITTER: Avery RR 

PROVIDER: S-EPMC12606439 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature