Impact of glucocorticoid dose threshold in definition of lupus low disease activity state: a multinational observational cohort study.

ABSTRACT:

Objectives

This study examined if lowering the glucocorticoid (GC) ceiling in the definition of lupus low disease activity state (LLDAS) from 7.5 mg/day to 5 mg/day (LLDAS-5) was associated with better outcomes in patients with systemic lupus erythematosus (SLE).

Methods

Data from a 13-country longitudinal SLE cohort (American College of Rheumatology/Systemic Lupus International Collaborating Clinics criteria), collected prospectively between 2013 and 2020, were analysed. Survival analyses were used to examine the longitudinal associations of LLDAS definitions with flare, organ damage accrual (frailty models) and mortality (Cox regression models).

Results

3801 patients with ≥2 visits were studied, with a median of 2.8 years (IQR: 1.0-5.4) of follow-up data (total visi

SUBMITTER: Kandane-Rathnayake R 

PROVIDER: S-EPMC12606472 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature