Mapping B cells and the immune landscape of tertiary lymphoid structures reveals their clinical impact in neuroblastoma.

ABSTRACT:

Background

Immunotherapy has transformed cancer treatment, highlighting the importance of effective antitumor immunity to fight cancer. However, its success in pediatric cancer remains limited, underscoring the urgent need to identify new immunotherapeutic targets. In this study, we explored the clinical relevance of B cells and tertiary lymphoid structures (TLS) in neuroblastoma (NB), a pediatric tumor with a heterogeneous immune landscape.

Methods

We analyzed 87 treatment-naïve NB specimens, spanning both localized and metastatic disease previously characterized for T-cell and dendritic cell (DC) infiltration. B cells were detected by immunohistochemistry, and plasma cells were quantified using multiple immunofluorescence. Spatial organization and functional status of immu

SUBMITTER: Melaiu O 

PROVIDER: S-EPMC12606491 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature