Kidney failure risk equation to predict kidney transplant failure in individuals with an eGFR<30 mL/min/1.73 m²: a UK Renal Registry external validation and recalibration study.

ABSTRACT:

Objectives

To externally validate and subsequently repurpose/recalibrate the easily accessible kidney failure risk equation (KFRE) for a prevalent transplant population with an estimated glomerular filtration rate (eGFR)<30 mL/min/1.73 m². It also aims to evaluate the recalibrated KFRE's potential to improve clinical practice with a clinical utility assessment.

Design

Retrospective cohort study using UK Renal Registry data.

Setting

68 adult UK kidney centres.

Participants

4092 patients with grafts at least 2 years old and eGFR<30 mL/min/1.73 m² from 2009 to 2018.

Primary outcome measure

Death-censored allograft failure at 2 years, defined as dialysis initiation, re-transplantation or, in the absence of the former two, the recorded date of tran

SUBMITTER: Masoud S 

PROVIDER: S-EPMC12606495 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature