Prevalence of germline pathogenic variants in 779 patients with metastatic prostate cancer.

ABSTRACT:

Objective

To assess the prevalence of germline pathogenic variants (gPVs) in genes associated with female breast cancer in Dutch patients with metastatic prostate cancer (mPCa).

Patients and methods

In this prospective multicentre cohort study (n = 15 centres), germline genetic testing of the genes BRCA1, BRCA2, ATM, CHEK2 and PALB2 was offered to patients with mPCa. We assessed the prevalence of gPVs and compared it to a reference population of 16 823 individuals who underwent genetic testing for non-oncological conditions. Additionally, we identified factors that increased the likelihood of carrying a gPV.

Results

A total of 779 patients with mPCa underwent germline genetic testing, of whom 46 (5.9%) had a gPV in a DNA damage repair gene. Most gPVs were found in CHE

SUBMITTER: Vlaming M 

PROVIDER: S-EPMC12606540 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature