Development of Dendritic Cell Membrane-Coated Nanoparticles for Antigen-Specific T-Cell Engagement.

ABSTRACT: Dendritic cell (DC) membrane-coated nanoparticles (DCmPs) hold significant potential for antigen-specific therapies. DCmPs carry key DC membrane proteins that facilitate DC-T cell interaction, such as the major histocompatibility complex (MHC), costimulatory CD80/86, and adhesive molecules ICAM-1. However, our current understanding of the impact of the coating processes and the composition of the final products is very limited, significantly hindering the development of DCmP-based therapy. Here, using DC2.4 cell membrane proteins and poly(lactic-co-glycolic acid) (PLGA) nanoparticles, we comprehensively characterized and compared the compositions and functions of DCmPs produced using sonication, extrusion, and a newly developed combined coating approach (sonication coating followed

SUBMITTER: Puth S 

PROVIDER: S-EPMC12606551 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature