Aminolyzed Polycaprolactone Nanofiber Scaffolds with Visible Light-Activated Sterilization for Tissue Engineering Applications.

ABSTRACT: New photoactive nanofiber materials based on an aminolyzed polycaprolactone membrane with demonstrated cytocompatibility were developed. Two photoactive compounds, the photosensitizer Rose Bengal and the nitric oxide photodonor 4-nitro-3-(trifluoromethyl)aniline, were covalently bonded to the nanofiber surface, with or without a glutaraldehyde linker. The surface functionalization was confirmed via X-ray photoelectron spectroscopy, UV-vis absorption, and steady-state and time-resolved luminescence spectroscopy. Upon excitation with green or blue light, these materials efficiently generate antibacterial species, including singlet oxygen, with a slight contribution of hydrogen peroxide and nitric oxide. A potent light-induced antibacterial effect was demonstrated against Escherichia coli<

SUBMITTER: Willimetz R 

PROVIDER: S-EPMC12606562 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature