Infective endocarditis meets native vertebral osteomyelitis: a mortality perspective.

ABSTRACT: Background: Native vertebral osteomyelitis and infective endocarditis (NVO + IE) are increasingly recognized as overlapping entities, sharing common risk factors (e.g., advanced age, immunosuppression) and similar pathogen profiles, most commonly Staphylococcus aureus and streptococci. Concurrent infection presents unique diagnostic and therapeutic challenges, leading to uncertainty regarding clinical outcomes and mortality. Therefore, we aimed to systematically evaluate the combined mortality associated with concomitant NVO + IE and to summarize the available clinical characteristics from published studies. Methods: A systematic review was conducted following the PRISMA framework. The databases searched included MEDLINE, Embase, Cochrane Library, and Scopus from 1970

SUBMITTER: Borgonovo F 

PROVIDER: S-EPMC12606593 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature