Capecitabine-loaded NLC for Breast Cancer Treatment: Preparation, Characterization, and <i>In vitro</i> Evaluation.

ABSTRACT:

Background

Cancer treatment often involves the use of potent antineoplastic drugs like Capecitabine (CAP), which can lead to serious toxicities. There is a need for dosage forms to manage these toxicities that can deliver the medication effectively to the target site while maintaining therapeutic efficacy at lower doses. To achieve the aforesaid objective, NLC containing capecitabine (NANOBIN) was prepared and evaluated. Different formulations of NANOBIN, denoted as CaTS, CaT1S, CaT2S, CaTS1, and CaTS2, were designed and evaluated to improve drug delivery and therapeutic outcomes.

Methods

The NANOBIN formulations were prepared using the hot homogenization method. The characterization of these formulations was conducted based on various parameters such as particle size, Polyd

SUBMITTER: Sultan MH 

PROVIDER: S-EPMC12606612 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature