Mechanisms of a Patented Chinese Herbal Medicine for Treating Hypothyroidism in <i>In Vitro</i> Fertilization-Embryo Transfer: A Combination of Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation.

ABSTRACT:

Background

Qu's formula 6 (QUF6), a patented Chinese herbal medicine, is used to treat hypothyroidism in the context of in vitro fertilization-embryo transfer (IVF-ET). This research aims to identify the potential bioactive components and elucidate the underlying molecular mechanisms by which QUF6 cures hypothyroidism during IVF-ET.

Materials and methods

To find the active components of QUF6, the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and relevant literature were searched. GeneCards and other resources were used to find the targets associated with hypothyroidism and IVF-ET. Using Cytoscape software, the network of interactions was created between the targets and components, the proteinprotein interaction (PPI) network was bui

SUBMITTER: Liu C 

PROVIDER: S-EPMC12606615 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature